389 Association between short-term exposure to environmental air pollution and atopic dermatitis flare under treatment with dupilumab

The magnitude of the short/medium-term air pollution exposure on atopic dermatitis (AD) flare has not been fully investigated. aim study is to investigate association airborne AD flares in patients treated with dupilumab. This an observational case-crossover study. Patients moderate-to-severe under treatment dupilumab were included. interest was mean concentrations coarse and fine particulate matter (PM10,PM2.5), nitrogen dioxide oxides (NO2,NOx). Different intervals considered at 1-60 days prior control visit, defined as visit highest EASI≤7, respectively. A conditional logistic regression analysis adjusted for systemic treatments employed estimate incremental risks (IR%) every 10 μg/m3 pollutants concentration. Data 169 out 528 1130 follow-up visits 5840 pollutant measurements retrieved. age 41.4±20.3 years; 94(55%) men. IR% curve indicated a significant positive trend all time windows. At 60 days, PM10,PM2.5,NOx NO2 increase concentration associated 82%,67%,28% 113% risk flare, In conclusion, dupilumab, acute increased dose-response relationship.